well more specifically I think one clear difference is the AET of 5 for coloseum and AET=7 for neoladder. The latter works out usually if you have a lifestyle or timetable where you can only "guarantee" a long freetime period at weekends (fri night, sat sun) ( or once a week= 7 days) . No matter which real day (sat Sun, Mon, Tue...) your opponent plays, then in neoladder you will always be able to make your main moves on a weekend if thats your only available time. Whereas with coloseum sometimes its gonna be really awkward or impossible. If your opponent plays on saturday and you dont catch it the very next day, or you dont want to quickly react, then in coloseum you simply cant wait to the following weekend as you get AET on Thursday! But with neoladder you can wait, its different. QED.
Of course you still need to visit mid-week for a quick check of status and make some uncritical moves so not to get booted.
(I also find this useful so i can even go to bed after a quick 5 minute look-over and start to think "a little" about overall plan.. like am i gonna keep attacking, or should I re-group... stuff like that... or just think about the CO differences and how one should be trying to use them --which can be done more or less without seeing the map.. he he.... so perhaps having less time mid-week actually often forces me to think more about whats going on)
Im wondering how many other players like to do their "difficult" plays at weekends... surely i cant be the only one? .......eeeek.
PS..of course not many days are so critical, and openings can often (not always) be done in a flash... and also endings.